The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/b3f90f47-895b-4380-bf26-a79f76e9f47a

Seale, Colm; Barazas, Marco; van Schendel, Robin; Tijsterman, Marcel; Gonçalves, Joana (2025): Data and code underlying the publication: MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis. Version 1. 4TU.ResearchData. software. https://doi.org/10.4121/b3f90f47-895b-4380-bf26-a79f76e9f47a.v1

Categories

• Artificial Intelligence and Image Processing
• Other Medical and Health Sciences
• Genetics
• Oncology and Carcinogenesis
• Information and Computing Sciences
• Biological Sciences
• Medical and Health Sciences

Keywords

compositional data analysis control-free CRISPR DNA damage response DNA repair isometric log-ratio transformation mahalanobis distance mutational spectra outlier detection

Licence

GPL-3.0

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by Colm Seale , Marco Barazas , Robin van Schendel , Marcel Tijsterman , Joana Gonçalves

This repository consists of code to reproduce the results of the paper "MUSICiAn: Genome-wide Identification of Genes Involved in DNA Repair via Control-Free Mutational Spectra Analysis".

The code to reproduce the paper is shared at: https://github.com/joanagoncalveslab/MUSICiAn

No experimental data was collected as part of this project, this project only utilised previously publicly available datasets. Details on accessing this data are fully described in the Methods section; "Data and preprocessing", "Mutational outcome data".

History

• 2025-02-18 first online, published, posted

Publisher

4TU.ResearchData

Format

Python scripts, slurm batch scripts, apptainer definition and build files, and configuration files for reproducing paper figures.

References

• https://doi.org/10.1101/2025.01.27.635038

Code hosting project url

https://github.com/joanagoncalveslab/MUSICiAn

Funding

• United States National Institutes of Health (grant code U54EY032442 to J.P.G.) United States National Institutes of Health
• Holland Proton Theraphy Center (grant code 2019020 to C.S.) Holland Proton Theraphy Center

Organizations

TU Delft, Faculty of Electrical Engineering, Mathematics and Computer Science, Department of Intelligent Systems, Pattern Recognition & Bioinformatics
Leiden University Medical Centre, Department of Human Genetics