Plath, Timo; Lansink, Matthijs; Fokkink, Harm; Hermans, Joep; Imankarijo, Siddieq et. al. (2024): Data and code underlying the publication: Rapid Prototyping of a Twin-Screw Granulator for lab-scale research. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/4bfdbdc1-7b23-4fc0-82e0-b0956308a341.v1

Dataset

x choose version: version 2 - 2024-11-07 (latest)

• Mechanical Engineering
• Other Engineering
• Pharmacology and Pharmaceutical Sciences
• Biomedical Engineering
• Other Manufacturing
• Chemical Engineering
• Engineering
• Manufacturing
• Mathematical Sciences
• Medical and Health Sciences

Additive manufacturing, Continuous manufacturing, Reverse engineering, Twin-screw wet granulation, Virtual prototyping

01-June-2021 to 01-September-2024

CC BY 4.0

RefWorks, BibTeX, Reference Manager, Endnote, DataCite, NLM, DC, CFF

by Timo Plath , Matthijs Lansink , Harm Fokkink , Joep Hermans , Siddieq Imankarijo , Thijs Brinks , Bas van de Veen , Rik Barlo , Prudhvi Gali , Thomas Weinhart

Twin-screw wet granulation has emerged as a promising solution for continuous manufacturing in the pharmaceutical sector, characterised by its flexibility and ability to produce granules with improved quality and homogeneity. However, challenges related to product formulations and twin-screw geometry affect granule properties, making lab-scale experiments costly. The study underlying this dataset explores the feasibility of using additive manufacturing to develop a functional and transparent twin-screw granulator for lab-scale research. Various printing methods, namely selective laser sintering, fused deposition modelling, and stereolithography, were evaluated for their manufacturing accuracy and surface roughness. An additive manufacturable twin-screw granulator design is proposed based on the Pharma 11 by Thermo Scientific Fisher. The granulator was successfully printed and tested in dry granulation experiments with sesame and canihua, revealing challenges such as gear slip. While the prototype serves as a proof of concept, some optimisation opportunities remain. This dataset contains all CAD files to construct your own twin-screw granulator for lab-scale research. Furthermore, it contains fully working copies of python tools and data (roughness data, measurement data) to plot the figures of the study, verify integrity and make this dataset reusable according to the FAIR principles.

• 2024-11-06 first online, published, posted

4TU.ResearchData

Spreadsheets (.csv, .xlsx), images (.eps, .jpg), code files (.py), video (.mp4) and CAD files (.STL, .STEP, .SLDASM, .SLDPRT)

• https://doi.org/10.1016/j.ijpharm.2019.119004
• https://doi.org/10.1016/j.powtec.2017.12.068
• https://doi.org/10.1016/j.arabjc.2021.103598

• Virtual Prototyping of Particulate Processes (ViPr) – Design and Optimisation via Multiscale Modelling and Rapid Prototyping (grant code 16604) [more info...] Dutch Research Council

University of Twente, Faculty of Engineering Technology, Department of Thermal and Fluid Engineering (TFE)