The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/16866358

Kuijpers, Louis; Nynke Dekker; Belen Solano Hermosilla; Richard Janissen (2021): Data underlying the publication: Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/16866358.v1

Dataset

• Microbiology

Magnetic tweezer data, magnetic tweezers, RdRP activity, RdRp pausing, virological characterizations

CC BY 4.0

• Data underlying the publication: Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses

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by Louis Kuijpers , Nynke Dekker, Belen Solano Hermosilla, Richard Janissen

The research object was the characterization of two enterovirus RNA-dependent RNA polymerases using multiplexed magnetic tweezers, to investigate snap-back synthesis and recombination. Presented here are in vitro measurements of the bead position during RNA replication. Bead position measurements were taken for 2 hours a constant pulling force of 25 pN at 24C at a camera acquisition rate of 50 Hz. Traces were cropped from the start until the end of the change in z-position, which was converted to nucleotides.

• 2021-10-26 first online, published, posted

4TU.ResearchData

Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses

• Human Frontiers Science Program (RPG0011/2015)

TU Delft, Faculty of Applied Sciences, Kavli Institute of Nanoscience, Department of Bionanoscience