The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/19235793

Tiemeijer, Laura A.; Ristori, Tommaso; Stassen, O. M. J. A. (Oscar); Ahlberg, Jaakko; de Bijl, Jonne J. J. et. al. (2022): Computational code underlying the publication “Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting”. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/19235793.v1

Dataset

• Biomedical Engineering
• Biochemistry and Cell Biology

endothelial sprouting, micropatterning, Notch ligand Dll4, Notch ligand Jag1

CC BY 4.0

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by Laura A. Tiemeijer, Tommaso Ristori, O. M. J. A. (Oscar) Stassen , Jaakko Ahlberg, Jonne J. J. de Bijl, Christopher S. Chen, Katie Bentley, C. V. C (Carlijn) Bouten , C. M. (Cecilia) Sahlgren

Spatial regulation of angiogenesis is important for the generation of functional engineered vasculature and the Notch ligands Jag1 and Dll4 are known to regulate endothelial sprouting. In this project, in vitro and in silico models were used to analyze the ability of micropatterned Jag1 and Dll4 to spatially control the sprouting process. Dll4 patterns, but not Jag1 patterns, were found to elicit spatial control and computational simulations suggest different timing of Notch activation by Jag1 and Dll4 to be the reason for their distinct effects. The more potent spatial control of sprouting by Dll4 in comparison to Jag1 could be exploited as a tool in vascular engineering and regenerative medicine.

This dataset contains computational modeling data simulating cell-cell signaling mediated by Notch ligands Jag1 and Dll4 during controlled endothelial sprouting.

• 2022-05-06 first online, published, posted

4TU.ResearchData

computational modeling data (.m, .mat)

Engineered patterns of Notch ligands Jag1 and Dll4 elicit differential spatial control of endothelial sprouting

• 10.4121/19235784

• MECHANOREGULATION OF JAGGED IN VASCULAR TISSUE HOMEOSTASIS (grant code 307133) [more info...] Academy of Finland
• Spatiotemporal Control of Cell Functions (grant code 316882) [more info...] Academy of Finland
• Multilayer mechanosignalling in vascular homeostasis-SIGNALSHEETS (grant code 330411) [more info...] Academy of Finland
• Investigating the crosstalk between Notch and YAP/TAZ in sprouting angiogenesis (grant code 846617) [more info...] European Commission
• The integration of cell signalling and mechanical forces in vascular morphology (grant code 771168) [more info...] European Research Council
• Doctoral Network in Molecular Biosciences at Åbo Akademi University
• Cellular Adaptive Behaviour Laboratory (grant code FC001751) [more info...] Cancer Research UK
• Materials-driven regeneration: Regenerating tissue and organ function with intelligent, life-like materials (grant code 024.003.013) [more info...] Dutch Research Council
• InFLAMES: Innovation Ecosystem based on the Immune System (grant code 337531) [more info...] Academy of Finland
• Åbo Akademi University Foundation’s Center of Excellence in Cellular Mechanostasis

Faculty for Science and Engineering, Biosciences, Åbo Akademi University, Turku,Finland
Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, Eindhoven, The Netherlands
The Biological Design Center and Department of Biomedical Engineering, Boston University, Boston, USA
Turku Bioscience Centre, Åbo Akademi University and University of Turku, Finland
The Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, USA
The Francis Crick Institute, London, UK
Department of Informatics, King’s College London, UK