The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/b56a1c97-20fb-4030-b838-ed4643c4f1c7

Till, Katharina; Seinen, Anne-Bart; Wruck, Florian; Sunderlikova, Vanda; Galmozzi, Carla V. et. al. (2025): Data underlying the publication: Trigger factor accelerates nascent chain compaction and folding . Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/b56a1c97-20fb-4030-b838-ed4643c4f1c7.v1

Categories

• Other Biological Sciences
• Other Physical Sciences
• Physical Sciences
• Biological Sciences

Keywords

chaperone optical tweezers protein folding selective ribosome profiling single-molecule

Licence

CC BY-SA 4.0

Interoperability

• RO-Crate Metadata

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by Katharina Till, Anne-Bart Seinen , Florian Wruck, Vanda Sunderlikova, Carla V. Galmozzi , Alexandros Katranidis , Bernd Bukau , Günter Kramer , Sander J. Tans

This dataset contains data collected during correlated single-molecule force spectroscopy and multi-color confocal laser scanning spectroscopy experiments at AMOLF, as part of Katharina Till's PhD Thesis project. The objective of the project behind this data was to study the conformational control mechanisms of chaperone assisted protein folding. Using selective ribosome profiling and optical tweezers with correlated single-molecule fluorescence, with dihydrofolate reductase (DHFR) as a model system, we show that the Escherichia coli chaperone trigger factor (TF) accelerates nascent chain folding. The data included in this data set has been organised per figure of the corresponding to be published publication. The excel sheet contains several tabs containing the underlying data to the figures they are named after. The data is being made public both to act as supplementary data for publications and the PhD thesis of Katharina Till and in order for other researchers to use this data in their own work.

History

• 2025-06-17 first online, published, posted

Publisher

4TU.ResearchData

Format

Microsoft Excel Worksheet (.xlsx)

Organizations

AMOLF (Amsterdam)
Center for Molecular Biology of Heidelberg University (ZMBH)