van Galen, Martijn; Bok, Annemarie; Peshkovsky, Taieesa; van der Gucht, Jasper; Albada, Bauke et. al. (2023): Dataset underlying publication: De novo DNA-based catch bonds. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e.v1

Dataset

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• Condensed Matter Physics
• Nanotechnology
• Physical Sciences
• Technology

Catch bonds, DNA nanotechnology, Mechanochemistry, Rolling adhesion, Supramolecular adhesion

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2019-2023

CC BY 4.0

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by Martijn van Galen, Annemarie Bok, Taieesa Peshkovsky, Jasper van der Gucht, Bauke Albada, Joris Sprakel

All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the materials constructed from them. Biological materials combine plasticity with strength, for which nature has evolved a unique solution: catch bonds, supramolecular interactions that strengthen under tension. Biological catch bonds use force-gated conformational switches to convert weak bonds into strong ones. To date, catch bonds remain exclusive to nature, leaving their potential as mechano-adaptive elements in synthetic systems untapped. Here, we report the design and realization of artificial catch bonds. Starting from a minimal set of thermodynamic design requirements, we created a molecular motif capable of catch bonding. It consists of a DNA duplex featuring a cryptic domain that unfolds under tension to strengthen the interaction. We show that these catch bonds recreate force-enhanced rolling adhesion, a hallmark feature of biological catch bonds in bacteria and leukocytes. This work introduces catch bonds into the synthetic domain.

• 2023-07-10 first online, published, posted

4TU.ResearchData

• https://dna.physics.ox.ac.uk/index.php/Main_Page

• The work of Martijn van Galen is financially supported by VLAG Graduate School VLAG Graduate School
• Joris Sprakel, Annemarie Bok and Martijn van Galen are funded by the European Research Council (ERC) project CoG-CATCH (grant code CoG-CATCH) European Research Council

Laboratory of Biochemistry, Wageningen University & Research
Physical Chemistry and Soft Matter, Wageningen University & Research
Laboratory of Organic Chemistry, Wageningen University & Research