Dataset underlying publication: De novo DNA-based catch bonds

doi: 10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e.v1
The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e
Datacite citation style:
van Galen, Martijn; Bok, Annemarie; Peshkovsky, Taieesa; van der Gucht, Jasper; Albada, Bauke et. al. (2023): Dataset underlying publication: De novo DNA-based catch bonds. Version 1. 4TU.ResearchData. dataset.
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite
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All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the materials constructed from them. Biological materials combine plasticity with strength, for which nature has evolved a unique solution: catch bonds, supramolecular interactions that strengthen under tension. Biological catch bonds use force-gated conformational switches to convert weak bonds into strong ones. To date, catch bonds remain exclusive to nature, leaving their potential as mechano-adaptive elements in synthetic systems untapped. Here, we report the design and realization of artificial catch bonds. Starting from a minimal set of thermodynamic design requirements, we created a molecular motif capable of catch bonding. It consists of a DNA duplex featuring a cryptic domain that unfolds under tension to strengthen the interaction. We show that these catch bonds recreate force-enhanced rolling adhesion, a hallmark feature of biological catch bonds in bacteria and leukocytes. This work introduces catch bonds into the synthetic domain.

  • 2023-07-10 first online, published, posted
  • The work of Martijn van Galen is financially supported by VLAG Graduate School VLAG Graduate School
  • Joris Sprakel, Annemarie Bok and Martijn van Galen are funded by the European Research Council (ERC) project CoG-CATCH (grant code CoG-CATCH) European Research Council
Laboratory of Biochemistry, Wageningen University & Research
Physical Chemistry and Soft Matter, Wageningen University & Research
Laboratory of Organic Chemistry, Wageningen University & Research


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