Dataset underlying publication: De novo DNA-based catch bonds

doi: 10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e.v1
The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e
Datacite citation style:
van Galen, Martijn; Bok, Annemarie; Peshkovsky, Taieesa; van der Gucht, Jasper; Albada, Bauke et. al. (2023): Dataset underlying publication: De novo DNA-based catch bonds. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e.v1
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Dataset
Wageningen University and Research logo
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geolocation
Wageningen University and Research
lat (N): 51.984
lon (E): 5.6615
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time coverage
2019-2023
licence
cc-by.png logo CC BY 4.0

All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the materials constructed from them. Biological materials combine plasticity with strength, for which nature has evolved a unique solution: catch bonds, supramolecular interactions that strengthen under tension. Biological catch bonds use force-gated conformational switches to convert weak bonds into strong ones. To date, catch bonds remain exclusive to nature, leaving their potential as mechano-adaptive elements in synthetic systems untapped. Here, we report the design and realization of artificial catch bonds. Starting from a minimal set of thermodynamic design requirements, we created a molecular motif capable of catch bonding. It consists of a DNA duplex featuring a cryptic domain that unfolds under tension to strengthen the interaction. We show that these catch bonds recreate force-enhanced rolling adhesion, a hallmark feature of biological catch bonds in bacteria and leukocytes. This work introduces catch bonds into the synthetic domain.

history
  • 2023-07-10 first online, published, posted
publisher
4TU.ResearchData
funding
  • The work of Martijn van Galen is financially supported by VLAG Graduate School VLAG Graduate School
  • Joris Sprakel, Annemarie Bok and Martijn van Galen are funded by the European Research Council (ERC) project CoG-CATCH (grant code CoG-CATCH) European Research Council
organizations
Laboratory of Biochemistry, Wageningen University & Research
Physical Chemistry and Soft Matter, Wageningen University & Research
Laboratory of Organic Chemistry, Wageningen University & Research

DATA

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