%0 Generic
%A van Galen, Martijn
%A Bok, Annemarie
%A Peshkovsky, Taieesa
%A van der Gucht, Jasper
%A Albada, Bauke
%A Sprakel, Joris
%D 2023
%T Dataset underlying publication: De novo DNA-based catch bonds
%U 
%R 10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e.v1
%K Catch bonds
%K Mechanochemistry
%K DNA nanotechnology
%K Rolling adhesion
%K Supramolecular adhesion
%X <p>All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the materials constructed from them. Biological materials combine plasticity with strength, for which nature has evolved a unique solution: catch bonds, supramolecular interactions that strengthen under tension. Biological catch bonds use force-gated conformational switches to convert weak bonds into strong ones. To date, catch bonds remain exclusive to nature, leaving their potential as mechano-adaptive elements in synthetic systems untapped. Here, we report the design and realization of artificial catch bonds. Starting from a minimal set of thermodynamic design requirements, we created a molecular motif capable of catch bonding. It consists of a DNA duplex featuring a cryptic domain that unfolds under tension to strengthen the interaction. We show that these catch bonds recreate force-enhanced rolling adhesion, a hallmark feature of biological catch bonds in bacteria and leukocytes. This work introduces catch bonds into the synthetic domain.</p>
%I 4TU.ResearchData