The DOI displayed above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
DOI: 10.4121/e12cc475-432a-4315-bc64-15a8888e3571

Passier, Margot; Bentley, Katie; Loerakker, Sandra; Ristori, Tommaso (2024): Data underlying the publication: YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico . Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/e12cc475-432a-4315-bc64-15a8888e3571.v1

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Categories

• Biomedical Engineering
• Engineering

Keywords

angiogenesis Computational model endothelial cells mechanoregulation Notch YAP/TAZ

Licence

CC BY 4.0

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by Margot Passier , Katie Bentley, Sandra Loerakker, Tommaso Ristori

Data belonging to the article "YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico"

It contains the MATLAB code used to run all simulations, the fitting algorithms and the code used to obtain all Figures.

The study focused on the mechanoresponse of Notch and in turn, that of angiogenesis. We hypothesized that this response could be explained through Notch interactions with mechano-sensitive YAP/TAZ. The modeled implementation was used to also investigate and suggest avenues through which to steer angiogenesis; by cytoskeletal manipulations and heterogeneous stiffness patterns.

DOI: https://doi.org/10.1038/s41540-024-00444-3

History

• 2024-10-08 first online, published, posted

Publisher

4TU.ResearchData

Format

MATLAB code/.m; README/.txt

Associated peer-reviewed publication

YAP/TAZ drives Notch and angiogenesis mechanoregulation in silico

Organizations

TU Eindhoven, Department of Biomedical Engineering
TU Eindhoven, Institute for Complex Molecular Systems (ICMS)