Furtado, Danielle; Leite, F.B.V.M (Fernando); Barreto, C.N (Cleber); Faria, B. (Bernadete); Jedlicka, L.D.L (Leticia) et. al. (2016): Profiles of Amino Acids and Biogenic Amines in the Plasma of Cri-du-Chat Patients from Brazil. Version 1. 4TU.ResearchData. dataset. https://doi.org/10.4121/uuid:62c3e6a1-1827-4308-9d23-2d3098483ad9

Dataset

• Medical Biochemistry and Metabolomics

Chemometrics, Cri-Du-Chat syndrome (CDCS), Mass spectrometry, Metabolomics

4TU General Terms of Use

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by Danielle Furtado , F.B.V.M (Fernando) Leite , C.N (Cleber) Barreto , B. (Bernadete) Faria , L.D.L (Leticia) Jedlicka , E.J (Elizangela) Silva , H.D.T (Heron) Silva , E.J.H (Etelvino) Bechara , N.A (Nilson) Assunção

The publication describes a metabolomic analysis with a chemometric approach, that allowed description of the metabolic profile of Cri Du Chat Syndrome (CDCS) as compared to normal subjects. Methods In the present work, UHPLC/MS was employed to analyze blood samples withdrawn from CDCS carriers (n=18) and normal parental subjects (n=18), and a representative CDCS profile was constructed from 33 targeted amino acids and biogenic amines. The result showed, an increase of methionine sulfoxide was of particular concern with respect to CDCS redox balance. Increased serotonin, methionine sulfoxide, and Asp levels, and a little lower Orn, citrulline, Leu, Val, Ile, Asn, Gln, Trp, Thr, His, Phe, Met, and creatinine levels were found in the plasma of CDCS patients. Nitrotyrosine and Trp did not differ in normal and CDCS individuals.

• 2016-09-23 first online, published, posted

UNIFESP - Universidade Federal de São Paulo

media types: application/octet-stream, application/pdf, application/zip, text/plain

• https://doi.org/10.1016/j.jpba.2017.03.034

Núcleo de Aconselhamento em Pesquisa Cri Du Chat