Data relating to Fuel-Driven Macromolecular Coacervation in Complex Coacervate Core Micelles

doi: 10.4121/19500368.v1
The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/19500368
Datacite citation style:
Lewis, Reece; Eelkema, Rienk; Klemm, Benjamin; Macchione, Mariano (2022): Data relating to Fuel-Driven Macromolecular Coacervation in Complex Coacervate Core Micelles. Version 1. 4TU.ResearchData. dataset.
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

In this work a chemical reaction network (CRN) is used to drive the coacervation of macromolecular species. The CRN enables transient quaternization of tertiary amine substrates, driven by the conversion of electron deficient allyl acetates and thiol or amine nucleophiles. By incorporating tertiary amine functionality into block copolymers, we demonstrate chemical triggered complex coacervate core micelle (C3M) assembly and disassembly. In contrast to most dynamic coacervate systems, this CRN operates at constant physiological pH without the need for complex biomolecules. By varying the allyl acetate fuel, deactivating nucleophile and reagent ratios, we achieved both sequential signal-induced C3M (dis)assembly, as well as transient non-equilibrium (dis)assembly.

  • 2022-04-04 first online, published, posted
Images as .tif; tabulated data in .xlsx; NMR data as raw .fid files
  • Signal Transduction in Organic Materials (grant code 726381) [more info...] European Research Council
TU Delft, Faculty of Applied Sciences, Department of Chemical Engineering, Advanced Soft Matter group


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