Data underlying the publication: Activation of PAR-2/p-ERK/GPX4 axis is involved in MCT-induced PAH and hypoxia-induced PASMCs proliferation
doi: 10.4121/534cc141-f45b-4cdb-b61b-7b34d80f035a
Title of the dataset: Data underlying the publication: Activation of PAR-2/p-ERK/GPX4 axis is involved in MCT-induced PAH and hypoxia-induced PASMCs proliferation. The dataset contains 5 pictures and 37 files in pzfx format. The 37 files in pzfx format contain experimental data related to the content of the pictures. For example, "Fig1A. media to vessel diameter ratio.pzfx" contains the data of "media to vessel diameter ratio" shown in A in Fig 1. There are a total of 5 pictures: Fig 1: Formation of MCT-induced rats PAH. Fig 2: An increase in the expression of protein PAR-2, p-ERK and GPX4 was observed in the lung tissue of rats with MCT-induced PAH. Fig 3: Hypoxia induces a time-dependent proliferation of PASMCs within 6 hours, accompanied by increased expression of PAR-2, p-ERK and GPX4. Fig 4: FSLL, a PAR-2 inhibitor, inhibited hypoxia-induced proliferation and regulated the expression of PAR-2, p-ERK and GPX4 in rat PASMCs. Fig5: Inhibition of MEK1/2/p-ERK with U0126 suppressed hypoxia-induced proliferation in rat PASMCs and regulated the expression of PAR -2 ,p - ERK,and GPX4. The research objectives are MCT-induced PAH rats and PASMCs. The type of research is an experimental prospective study. Methodology for data collection and type: All data collected were from animal and cells experiments, with all data types being numerical.
- 2024-09-12 first online, published, posted
- Activation of PAR-2/p-ERK/GPX4 axis is involved in MCT-induced PAH and hypoxia-induced PASMCs proliferation Soochow Health Committee of Science and Technology Projects
The Second People's Hospital of Huai’an, Huai’an, Jiangsu, China.
DATA
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README.txt - 165,863 bytesMD5:
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Fig 1.jpg - 128,400 bytesMD5:
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Fig 2.jpg - 251,432 bytesMD5:
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Fig 3.jpg - 248,949 bytesMD5:
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Fig 4.jpg - 244,350 bytesMD5:
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Fig 5.jpg - 89,890 bytesMD5:
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Fig1A. media to vessel diameter ratio.pzfx - 127,446 bytesMD5:
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Fig1A. the degree of musculature.pzfx - 35,631 bytesMD5:
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Fig1B. myocardial fibrosis scores increased in MCT model at 4w.pzfx - 89,600 bytesMD5:
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Fig1B. right ventricular index in Mod.pzfx - 89,551 bytesMD5:
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Fig1C. PASP in two groups.pzfx - 294,659 bytesMD5:
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Fig2A. GPX4 by IHC.pzfx - 303,473 bytesMD5:
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Fig2A. p-ERK by IHC.pzfx - 171,286 bytesMD5:
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Fig2A. PAR-2 by IHC.pzfx - 211,558 bytesMD5:
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Fig2B. GPX4.pzfx - 210,159 bytesMD5:
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Fig2B. p-ERK.pzfx - 211,520 bytesMD5:
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Fig2B. PAR-2.pzfx - 93,631 bytesMD5:
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Fig3A. BrdU Incorporation.pzfx - 95,298 bytesMD5:
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Fig3A. CCK-8 assay.pzfx - 167,727 bytesMD5:
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Fig3B. GPX4 by IF.pzfx - 167,234 bytesMD5:
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Fig3B. GPX4.pzfx - 168,206 bytesMD5:
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Fig3B. p-ERK by IF.pzfx - 168,157 bytesMD5:
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Fig3B. p-ERK.pzfx - 111,594 bytesMD5:
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Fig3B. PAR-2 by IF.pzfx - 39,158 bytesMD5:
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Fig3B. PAR-2.pzfx - 226,710 bytesMD5:
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Fig4A CELL COUNT.pzfx - 156,456 bytesMD5:
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Fig4A. BrdU Incorporation.pzfx - 159,008 bytesMD5:
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Fig4A. CCK-8 assay.pzfx - 237,716 bytesMD5:
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Fig4B. GPX4 by IF.pzfx - 237,718 bytesMD5:
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Fig4B. p-ERK by IF.pzfx - 182,441 bytesMD5:
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Fig4B. PAR-2 by IF.pzfx - 109,137 bytesMD5:
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Fig4C. GPX4.pzfx - 166,328 bytesMD5:
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Fig4C. p-ERK.pzfx - 38,399 bytesMD5:
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Fig4C. PAR-2.pzfx - 226,307 bytesMD5:
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Fig5A CELL COUNT.pzfx - 156,524 bytesMD5:
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Fig5A. BrdU Incorporation.pzfx - 209,702 bytesMD5:
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Fig5A. CCK-8 assay.pzfx - 237,730 bytesMD5:
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Fig5B. GPX4 by IF.pzfx - 237,761 bytesMD5:
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Fig5B. p-ERK by IF.pzfx - 181,629 bytesMD5:
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Fig5B. PAR-2 by IF.pzfx - 165,439 bytesMD5:
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Fig5C. u0126-GPX4.pzfx - 165,850 bytesMD5:
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Fig5C. u0126-p-ERK.pzfx - 109,169 bytesMD5:
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Fig5C. u0126-PAR-2.pzfx -
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