Data underlying the publication "Association of body mass index and waist circumference with long-term mortality risk in 10,370 coronary patients and potential modification by lifestyle and health determinants"

doi: 10.4121/0b66dd27-ee11-43f2-b58b-fff98463f944.v1
The doi above is for this specific version of this dataset, which is currently the latest. Newer versions may be published in the future. For a link that will always point to the latest version, please use
doi: 10.4121/0b66dd27-ee11-43f2-b58b-fff98463f944
Datacite citation style:
Cruijsen, Esther (2024): Data underlying the publication "Association of body mass index and waist circumference with long-term mortality risk in 10,370 coronary patients and potential modification by lifestyle and health determinants". Version 1. 4TU.ResearchData. dataset.
Other citation styles (APA, Harvard, MLA, Vancouver, Chicago, IEEE) available at Datacite

Body adiposity is known to affect mortality risk in patients with coronary artery disease (CAD). We examined associations of body mass index (BMI) and waist circumference (WC) with long term mortality in Dutch CAD patients, and potential and effect modification of these associations by lifestyle and health determinants.

10,370 CAD patients (mean age ~65 y; 20% female; >80% on cardiovascular drugs) from the prospective Alpha Omega Cohort and Utrecht Cardiovascular Cohort – Secondary Manifestations of ARTerial disease study were included. Cox models were used to estimate categorical and continuous associations (using restricted cubic splines) of measured BMI and WC with all-cause and cardiovascular mortality risk, adjusting for age, sex, smoking, alcohol, physical activity and educational level. Analyses were repeated in subgroups of lifestyle factors (smoking, physical activity, diet quality), education and health determinants (diabetes, self-rated health).

During ~10 years of follow-up (91,947 person-years), 3,553 deaths occurred, including 1,620 from cardiovascular disease. U-shaped relationships were found for

BMI and mortality risk, with the lowest risk for overweight patients (BMI ~27 kg/m2). For obesity (BMI ≥30), the HR for all-cause mortality was 1.31 (95% CI: 1.11, 1.41) in male patients and 1.10 (95% CI: 0.92, 1.30) in female patients, compared to BMI 25-30 kg/m2. WC was also non-linearly associated with mortality, and HRs were 1.18 (95%CI:1.06, 1.30) in males and 1.31 (95%CI:1.05, 1.64) in females for the highest vs. middle category of WC. Results for cardiovascular mortality were mostly in line with the results for all-cause mortality. U-shaped associations were found in most subgroups, associations were moderately modified by physical activity, smoking and educational level.

CAD patients with obesity and a large WC were at increased risk of longterm CVD and all-cause mortality, while mildly overweight patients had the lowest risk. These associations were consistent across subgroups of patients with different lifestyles and health status.

  • 2024-03-28 first online, published, posted
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Departement Agrotechnologie en Voedingswetenschappen, Wageningen University & Research

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Data comprise the minimal data set to reproduce results. The receiver must delete the data within 1 year and has to report to the provider that the data has been deleted. Data provider grants data receiver a non-exclusive, non-transferable, terminable licence to access, copy and use the data. The receiver can solely reproduce the results from the corresponding paper (‘Body mass index, waist circumference and mortality; potential modification by lifestyle and health factors’). Receiver is not allowed to share, publish or disseminate data findings without explicit consent of the data provider. The receiver guarantees that the data will be safeguarded from misuse and unauthorised access or disclosure. A hard copy of the data will be stored in a directory where only the receiver has access to. Data will be provided via encrypted data sharing software, e.g. Surffilesender, including a password after data request has been accepted by the data steward of the Department of Human Nutrition and Health (

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