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Data underlying the publication: "Lateral induction limits the impact of cell connectivity on Notch signaling in arterial walls"

posted on 20.10.2020, 13:18 by Tommaso Ristori, O. M. J. A. (Oscar) Stassen, C. M. (Cecilia) Sahlgren, S. (Sandra) Loerakker
This study extends a previous 1D agent-based model for Notch signaling in arteries to a 2D formulation. This allows investigation of the effects of cell connectivity on the dynamics of arterial Notch signaling and VSMC phenotypes. Notch signaling for VSMCs with 2-6 neighbouring cells was analyzed. Computational results of the 1D and 2D formulations were also compared.


The integration of cell signalling and mechanical forces in vascular morphology

European Research Council

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Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways

European Research Council

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Targeting Notch signalign in cancer

Academy of Finland

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Eindhoven University of Technology, Department of Biomedical Engineering; Åbo Akademi University, Faculty of Science and Engineering, Biosciences; Eindhoven University of Technology, Institute for Complex Molecular Systems