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Data relating to Fuel-Driven Macromolecular Coacervation in Complex Coacervate Core Micelles

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posted on 04.04.2022, 17:22 by Reece LewisReece Lewis, Rienk EelkemaRienk Eelkema, Benjamin Klemm, Mariano Macchione

In this work a chemical reaction network (CRN) is used to drive the coacervation of macromolecular species. The CRN enables transient quaternization of tertiary amine substrates, driven by the conversion of electron deficient allyl acetates and thiol or amine nucleophiles. By incorporating tertiary amine functionality into block copolymers, we demonstrate chemical triggered complex coacervate core micelle (C3M) assembly and disassembly. In contrast to most dynamic coacervate systems, this CRN operates at constant physiological pH without the need for complex biomolecules. By varying the allyl acetate fuel, deactivating nucleophile and reagent ratios, we achieved both sequential signal-induced C3M (dis)assembly, as well as transient non-equilibrium (dis)assembly.

Funding

Signal Transduction in Organic Materials

European Research Council

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History

Publisher

4TU.ResearchData

Format

Images as .tif; tabulated data in .xlsx; NMR data as raw .fid files

Organizations

TU Delft, Faculty of Applied Sciences, Department of Chemical Engineering, Advanced Soft Matter group