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Data accompanying the research on: Does Betamethasone therapy impact fetal multivessel doppler parameters?

posted on 01.05.2020, 00:00 by Halis Ozdemi̇rHalis Ozdemi̇r
This was a prospective cohort study. During March 2018–March 2019, 27 singleton pregnancies between 28 and 34 gestational weeks with a diagnosis threat of preterm birth were included prospectively. To be eligible, patients had to have received betamethasone and a loading dose of nifedipine for tocolysis, followed by hydration and maintenance nifedipine therapy for 48 h. Betamethasone (Celestone Cronodose, Schering-Plough, İstanbul, Turkey) was administered as two doses of 12 mg each, administered 24 h apart. Fetuses, who had intrauterine growth restriction (IUGR), oligohydramnios, polyhydramnios, or fetal anomaly were excluded from the study. Other maternal indications for exclusion were: preeclampsia, eclampsia, HELLP syndrome, premature preterm rupture of membranes, placenta previa, or any chronic maternal disease. Patients with diabetes mellitus (gestational or pregestational) were not included in the study. We prospectively evaluated fetal main pulmonary artery (MPA), left and right pulmonary artery (PA), left myocardial performance index (MPI, TEI index), tricuspid valve (TV), umbilical artery (UmA), middle cerebral artery (MCA), and ductus venous (DV) parameters before and at 48 h and 7 days after steroid administration. The Doppler indices of interest included Peak Systolic Velocity (PSV), Resistance Index (RI), Pulsatility Index (PI), Systolic/Diastolic ratio (S/D ratio), Acceleration Time/Ejection Time Ratio (AT/ET ratio) (MPA), E/A ratio (TV), left ventricle TEI index parameters (isovolumetric contraction time (ICT), isovolumetric relaxation time (IRT), ejection time (ET), and DV A wave.



Gazi University, Faculty of Medicine, Perinatology; Gynecology and Obstetry


4TU.Centre for Research Data


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