Data belonging to the publication: "Computational analysis of the role of mechanosensitive Notch signaling in arterial adaptation to hypertension"
This study couples a Finite Element model for arterial mechanics to an Agent-Based model for mechanosensitive Notch signaling among vascular smooth muscle cells to predict the phenotype of these cells under hypertension, a loss of residual stresses in the artery, and manipulations of the Notch signaling pathway. This dataset contains the codes for the Finite Element model, the Agent-Based model and the coupling between them, as well as the raw data generated by these models.
- 2022-07-07 first online, published, posted
- Predicting cardiovascular regeneration: integrating mechanical cues and signaling pathways (grant code 802967) [more info...] European Research Council
- The integration of cell signalling and mechanical forces in vascular morphology (grant code 771168) [more info...] European Research Council
- Investigating the crosstalk between Notch and YAP/TAZ in sprouting angiogenesis (grant code 846617) [more info...] European Commission
Institute for Complex Molecular Systems, Eindhoven University of Technology, the Netherlands
School of Engineering and Trinity Centre for Biomedical Engineering, Trinity College Dublin, Ireland
Faculty of Science and Engineering, Biosciences, Åbo Akademi, Turku, Finland