*** Effect of resveratrol on intestinal tight junction proteins and the gut microbiome in high-fat diet-fed insulin resistant mice *** 
Authors: Chen, K. (Kaiting)
Department of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, Hebei Province, People’s Republic of China;
Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, People’s Republic of China;
Department of Endocrinology, The First Hospital of Shijiazhuang, Shijiazhuang 050000, Hebei Province, People’s Republic of China
 
 
Corresponding author: Guangyao Song
 
Contact Information:  
 
guangyaosong123@163.com
 
Endocrinology Department, Hebei General Hospital
348 Heping West Road
Shijiazhuang, Hebei 050051
People’s Republic of China

 
***General Introduction*** 
This dataset contains data collected during resveratrol in high-fat diet-fedmice experiments. 
It is being made public both to act as supplementary data for publications and the PhD 
thesis of Kaiting Chen and in order for other researchers to use this data in their own 
work. 
 
The data in this data set was collected in Hebei Key Laboratory of Metabolic Diseases and the  Laboratory of BGI Genomics Co., Ltd., between June  2018 
and March  2019. 
This study was supported by the grant from the Natural Science Foundation of Hebei Province (No.H2018307071).. 
 
***Purpose of the test campaign*** 
The purpose of these experiments was to investigate  the effects of resveratrol (RES) on the gut microbiome in high-fat diet-fed insulin resistant mice . 
 
***Test equipment*** 
The 16S rDNA V3–V4 region (~454 bp) of the DNA samples was amplified using the primers 341F (5’-ACTCCTACGGGAGGCAGCAG-3’) and 806R (5’-GGACTACHVGGGTWTCTAAT -3’) and sequenced using MiSeq-based (2 × 300PE) (Illumina, San Diego, CA) .
 
***Description of the data in this data set***  
The data included in this data set has been organised per specimen. The files follow the 
nomenclature system:  
A = normal diet (ND) group
B = high-fat diet(HFD)group
C=HFD+RES group