This QScale - Experiment 2 readme.txt file was generated on 20230810 by N. Jansen

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GENERAL INFORMATION
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Title of Dataset: QScale - Experiment 2

Author Information (Name, Institution, Address, Email)

	Principal Investigator: Prof. dr. ir. Jan R. Buitenweg, University of Twente, Drienerlolaan 5, 7522 NB Enschede, j.r.buitenweg@utwente.nl
	Associate or Co-investigator: N. Jansen, MSc, University of Twente, Drienerlolaan 5, 7522 NB Enschede, n.jansen@utwente.nl

Date of data collection (single date, range, approximate date): 2015

Geographic location of data collection: University of Twente, Drienerlolaan 5, 7522 NB Enschede

Information about funding sources or sponsorship that supported the collection of the data: NA, the work was supported with internal funding from the University of Twente


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SHARING/ACCESS INFORMATION
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Licenses/restrictions placed on the data, or limitations of reuse: 

Recommended citation for the data: 10.4121/a1f9f68f-c429-4a46-8b34-75942f49a503

Citation for and links to publications that cite or use the data: TBD - When the article that links to this information becomes available

Links to other publicly accessible locations of the data: NA

Links/relationships to ancillary or related data sets: 10.4121/8f0707cd-f899-4dc2-ba42-830bd19d4b19 ('QScale - Experiment 3').


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DATA & FILE OVERVIEW
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File list (filenames, directory structure (for zipped files) and brief description of all data files): 'Dataset - Experiment 2 - Condensed.xlsx'

Relationship between files, if important for context: NA 

Additional related data collected that was not included in the current data package: NA

If data was derived from another source, list source: NA

If there are there multiple versions of the dataset, list the file updated, when and why update was made: NA


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METHODOLOGICAL INFORMATION
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Description of methods used for collection/generation of data: <Include links or references to publications or other documentation containing experimental design or protocols used in data collection>
At first, the (1) detection- (2) pain- and (3) pain tolerance threshold (DT, PT and PTT, respectively) were established by verbally instructing the participants to release the button as soon as the participant (1) started to feel the stimulus (2) started feeling painful and (3) started experiencing intolerable pain. During pressing the button, the provided stimulus increased from 0 to maximally 20 mA at a ramping speed of 0.3 mA/s. Three subsequent measurements are performed, which are averaged to determine the pain threshold.
Based on the individual DT, PT and PTT of each participant, in total seven individualized stimulus strengths were determined: at 25%, 50% and 75% of the difference between the DT and PT, at the PT, and at 25%, 50% and 75% of the difference between the PT and PTT. Stimuli of each intensity were applied ten times to the participants in a randomized series of 70 stimuli, each with a duration of 3 seconds. After each stimulus presentation, the participant was asked to select from each of the four visual quality representations of the QScale (A, B, C or D) the image representing the intensity level (1, 2, 3 or 4) that most closely matched the perceived sensation. For quality representations that did not match with the perceived sensation at all, the participants were asked to select the pre-drawn skin without drawings of a sensation (‘NA’). After presentation of the total series of stimuli, the DT, PT and PTT were established once more in order to evaluate any changes in nociceptive processing.
Electrical stimulation was provided via the AmbuStim PT (University of Twente, the Netherlands). This programmable constant current stimulator generates pulses of 100 Hz and a width of 210 ms, which are delivered to the skin amidst of the delta muscle of the right upper arm by patch electrodes (Red Dot 2560, 3M). The total surface area of a single electrode is 16x13.6 mm. 
All experiments have been conducted in accordance with the guidelines of the Declaration of Helsinki. All participants received written information and were asked to sign an informed consent prior to conducting the experiment. 

Software- or Instrument-specific information needed to interpret the data, including software and hardware version numbers:
Electrical stimulation was provided via the AmbuStim PT (University of Twente, the Netherlands). This programmable constant current stimulator generates pulses of 100 Hz and a width of 210 ms, which are delivered to the skin amidst of the delta muscle of the right upper arm by patch electrodes (Red Dot 2560, 3M). The total surface area of a single electrode is 16x13.6 mm. In the B-QS-CS group, electrical stimulation was delivered by the CutaStim, which is a interdigitated Ag/AgCl electrode with 4 anode legs and 3 cathode legs with the base of the legs covered in foam. Between each leg there is a distance of 2 mm and the surface area per leg is 3x17 mm. The CutaStim is expected to provide a more shallow stimulation profile as compared to the CutaStim, and thereby is hypothesized to activate sensory and nociceptive afferents only in the skin and in a different order, i.e. earlier activation of nociceptive afferents (e.g. see Leandri, Marinelli, Siri, & Pellegrino, 2018; Morch, Hennings, & Andersen, 2011), thereby also eliciting different sensations. 
QScale: An ordered set of visual representations comprising of 4 qualities (A-D) with each 4 levels of intensity (1-4). For each of the four qualities, an image of the pre-drawn skin without drawings of a sensation was added, to permit report of qualities not matching the perceived sensation (‘Not Applicable’, or ‘NA’).

Standards and calibration information, if appropriate:
NA

Environmental/experimental conditions:
All experiments were conducted at the University of Twente in a climate controlled room. 

Describe any quality-assurance procedures performed on the data:
Experiments were conducted in accordance with a standard operating procedure.

People involved with sample collection, processing, analysis and/or submission:
L. Hartl, M. Thijssen, N. Jansen, J. R. Buitenweg

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DATA-SPECIFIC INFORMATION <Create sections for each datafile or set, as appropriate>
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Number of variables: 103

Number of cases/rows: 60

Variable list, defining any abbreviations, units of measure, codes or symbols used:
Data per participant (N=9) is organized per individual tab (#1, #2, (...), #9)

A2:G5 		The detection-, pain- and tolerance threshold including the pain score on a numerical rating score ranging from 0 ('No pain') to 10 ('Most intense pain imaginable'). Three subsequent measurements (M1, M2 and M3) were made. Pre-experimental measurements.
A7:B10		The average of the three subsequent measurements to establish the detection-, pain and tolerance threshold. Pre-experimental measurements.
A12:C19		Calculation of the in total 7 individualized stimulus strengths at 25%, 50% and 75% of the difference between the DT and PT, at the PT, and at 25%, 50% and 75% of the difference between the PT and PTT

A21:G91		Row A ('#experiment')		Indicates the randomized individualized level that was applied
		Current				Indicates the stimulus strength applied, which corresponds to the individualized level (see also A12:C19)
		NRS				The perceived pain score ranging from 0 ('No pain') to 10 ('Most intense pain imaginable') in response to the stimulus being applied
		Row1				The perceived intensity of QScale quality 'A'. Here, 1 is 'not perceived'.
		Row2				The perceived intensity of QScale quality 'B'. Here, 1 is 'not perceived'.
		Row3				The perceived intensity of QScale quality 'C'. Here, 1 is 'not perceived'.
		Row4				The perceived intensity of QScale quality 'D'. Here, 1 is 'not perceived'.

A93:G96 	The detection-, pain- and tolerance threshold including the pain score on a numerical rating score ranging from 0 ('No pain') to 10 ('Most intense pain imaginable'). Three subsequent measurements (M1, M2 and M3) were made. Post-experimental measurements.
A98:B101	The average of the three subsequent measurements to establish the detection-, pain and tolerance threshold. Post-experimental measurements.
   
Missing data codes: NA

Specialized formats or other abbreviations used: NA