*** Calycosin-7-O-¦Â-D-glucoside attenuates OGD/R-induced damage by preventing oxidative stress and neuronal apoptosis via the SIRT1/FOXO1/PGC-1¦Á pathway in HT22 cells *** Authors: Xiangli Yan, Aiming Yu, Haozhen Zheng, Shengxin Wang, Yingying He, Lisheng Wang Guangzhou University of Chinese Medicine Corresponding author: Lisheng Wang Contact Information: wlis68@sina.com Guangzhou University of Chinese Medicine, 232 Outer Circle Road East, Panyu District, Guangzhou 510006, China ***General Introduction*** The dataset contains data collected during the study of the ischemic stroke in Guangzhou University of Traditional Chinese Medicine. As part of Dr. Yan Xiangli's thesis project, it is being published as the original data of the publication and Yan Xiangli's doctoral thesis. The data in this dataset was collected from the Chinese Medicine College of Guangzhou University of Traditional Chinese Medicine from 2017 to 2019. The research project was supported by National Natural Science Foundation of China (81873228), Science Program for Overseas Scholar of Guangzhou University of Chinese Medicine (XH20170108), and Project of Educational Commission of Guangdong Province (2017KZDXM018). ***Purpose of the study*** The purpose of this experiment was to investigate the mechanism of CG in promoting ischemic stroke recovery. The whole uncropped images of the original western blots have been named and uploaded and cell morphology pictures have been uploaded. The raw data of biochemical indicators can be found in "Biochemical Indicators". ***Test equipment*** All experiments used three-gas incubator, microplate reader, fluorescence microscope, flow cytometry, Bio-Rad ChemiDoc Touch Imaging System and ABI 7500 Sequence Detection System. Statistical analysis was performed by one-way analysis of variance with SPSS 17.0 software.