TY - DATA
T1 - Data underlying the article: A Revised Modular Approach to (–)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions
PY - 2019/10/14
AU - Victor Bloemendal
AU - D. (Daan) Sondag
AU - H. (Hidde) Elferink
AU - T.J. (Thomas) Boltje
AU - Jan van Hest
AU - F.P.J.T. (Floris) Rutjes
UR - https://data.4tu.nl/articles/dataset/Data_underlying_the_article_A_Revised_Modular_Approach_to_-trans-_8-THC_and_Derivatives_Through_Late-Stage_Suzuki_Miyaura_Cross-Coupling_Reactions/12715754/1
DO - 10.4121/uuid:cef2b72f-0e08-4f92-a700-6d3e098da134
KW - Cannabis derivatives
KW - Cascade reactions
KW - Heterocycles
KW - Suzuki-Miyaura coupling
KW - Tetrahydrocannabinol
N2 - A revised modular approach to various synthetic (–)-trans-Δ8-THC derivatives through late-stage Suzuki–Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp2- and sp3-hybridized cross-couplingpartners with minimal β-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki–Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.
ER -