TY - DATA
T1 - Data underlying the publication: Neuroprotective Effects of Everolimus via Regulation of Autophagy-Related Proteins in a Cerebral Ischemia-Reperfusion Rat Model
PY - 2024/08/01
AU - Shengling Fu
AU - Yu-cong Zhou
AU - Hu Fang
AU - Haoliang Ouyang
AU - Shihua Li
AU - Jinping Xiao
AU - Hao Liu
UR - 
DO - 10.4121/983ad43d-4fad-4808-ade9-d30a03d836bb.v1
KW - Cellular autophagy
KW - mTOR
KW - Beclin-1
KW - ischemic stroke
KW - everolimus
KW - Middle cerebral artery occlusion (MCAO)
KW - pPI3K
KW - PI3K
KW - pAkt
KW - Akt
N2 - <p>The data was collected from MCAO rats to evaluate the neuroprotection of everolimus. In excel file, the Longa’s neurological scale was applied to evaluate neurobehavioral deficit in ischemia/reperfusion-induced rats, and the ischemic infarct area of each section was calculated as infarct size. Besides, immunochemical staining of MCAO rats for mTOR and Beclin-1 expression was uploaded to observe the influence of everolimus on mTOR and Beclin-1. Besides, the data also included WB images of pPI3K, PI3K, pAkt, Akt, LC3-I, LC3-II. This study explored the effect of everolimus on the expression of PI3K, LC3, and Akt proteins and further clarified the regulatory mechanism of nerve cell autophagy against neural lesions.</p>
ER -