We identified significantly enriched KEGG pathways and corresponding genes in the BRAF mutant group via GSEA. For the first time, a prognostic signature based on seven BRAF-related genes with an independent prognostic value for melanoma patients and related to immune cell infiltration and checkpoint was constructed and validated. Furthermore, we established a nomogram based on the prognostic signature and independent clinical characteristics, providing a tool for the objective assessment of the survival rate of melanoma patients.