TY - DATA
T1 - Data of manuscript Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19
PY - 2024/09/17
AU - Huub Weener
AU - Thijs van Haaps
AU - Ruben van Helden
AU - Hugo Albers
AU - Rozemarijn Haverkate
AU - Heleen Middelkamp
AU - Milan Ridderikhof
AU - Thijs van Mens
AU - Albert van den Berg
AU - Christine Mummery
UR - 
DO - 10.4121/5bb846d8-ed30-4e2e-bfe3-4fb607cbe8ed.v1
KW - Clinical data
KW - ELISA
KW - Thrombosis
KW - Organ-on-Chip
KW - RNA sequencing
KW - Cytokine
KW - COVID-19
KW - Corona
N2 - <p>This dataset contains the data for the manuscript "Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19", to be published. Within the data are multiple sets:</p><ul><li>clinical data from included patients and controls; including admission time in hospital, diagnostic measurements when first included, outcome of admission, and VTE status during admission</li><li>Cytokine ELISAs of IL-6, IL-10, TNF-a, IFN-y, CXCL-10, measured in the derived plasma of hospitalized patients</li><li>Raw reads of RNA sequencing of hiPSC derived endothelial cells, after cells were stimulated with diluted patient plasma overnight to induce changes in their phenotype</li><li>Raw pathogen counts based on said RNA sequencing data, where non-human RNA reads are quantified per sample</li><li>Platelet coverage data after hiPSC-ECs were stimulated with derived plasma on-chip, where the stimulated chips were perfused with human whole blood to recapitulate the thrombotic adverse events that occur in some COVID patients.</li></ul>
ER -