TY - DATA
T1 - Data underlying the research of the Role of bacterial proteins in the onset of ANCA vasculitis
PY - 2022/01/18
AU - Frans Bianchi
AU - Peter Heeringa
AU - Myrthe Frans
AU - Anna van der Veen
AU - Jildau van der Ven
UR - https://data.4tu.nl/articles/dataset/Data_underlying_the_research_of_the_Role_of_bacterial_proteins_in_the_onset_of_ANCA_vasculitis/17171069/1
DO - 10.4121/17171069.v1
KW - MPO
KW - SPIN
KW - ANCA
KW - AAV
KW - vasculitis
KW - Anti-neutrophil cytoplasmic antibodies
KW - Myeloperoxidase
KW - 6pgd
N2 - <div><div>Goal: The aim of the project was to investigate whether S.aureus proteins SPIN and 6PGD via the formation of the hybrid auto-antigen SPIN:MPO or MPO mimitope 6PGD could explain the differential aetiologies of the disease GPA (Granulomatosis with polyangitis) caused by MPO-ANCA (Anti Neutrophil Cytoplasmic Autoantibodies).</div><div>Methods: Isolation kinetic verification of S.Aureus 6PGD and SPIN by means of Activity measurements, see Readme for further specifications. </div><div>Determination of antibody reactivity/titers using ELISA in sera from patients with MPO ANCA and healthy individuals against the hybrid auto-antigen MPO:ANCA or 6PGD, see Readme for further specifications. </div><div>Data: Antibody titers ELISA and (Kinetics) colorigenic activity assays.</div></div><div><br></div>
ER -