%0 Generic
%A Bloemendal, Victor
%A Sondag, D. (Daan)
%A Elferink, H. (Hidde)
%A Boltje, T.J. (Thomas)
%A van Hest, Jan
%A Rutjes, F.P.J.T. (Floris)
%D 2019
%T Data underlying the article: A Revised Modular Approach to (–)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions
%U https://data.4tu.nl/articles/dataset/Data_underlying_the_article_A_Revised_Modular_Approach_to_-trans-_8-THC_and_Derivatives_Through_Late-Stage_Suzuki_Miyaura_Cross-Coupling_Reactions/12715754/1
%R 10.4121/uuid:cef2b72f-0e08-4f92-a700-6d3e098da134
%K Cannabis derivatives
%K Cascade reactions
%K Heterocycles
%K Suzuki-Miyaura coupling
%K Tetrahydrocannabinol
%X A revised modular approach to various synthetic (–)-trans-Δ8-THC derivatives through late-stage Suzuki–Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp2- and sp3-hybridized cross-couplingpartners with minimal β-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki–Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.
%I 4TU.Centre for Research Data