%0 Generic
%A den Toonder, Jaap
%D 2022
%T Source data for the publication: Engineered modular microphysiological models of the human airway clearance phenomena
%U https://data.4tu.nl/articles/dataset/Source_data_for_the_publication_Engineered_modular_microphysiological_models_of_the_human_airway_clearance_phenomena/19923707/1
%R 10.4121/19923707.v1
%K Artificial Cilia
%K microphysiological model
%K human airway clearance
%K mucus models
%K Mucociliary transport
%K Magnetic actuation
%K Microfluidics
%X <p>This data set contains the source data of the publication: Pedersoli, L., Zhang, S., Briatico-Vangosa, F., Petrini, P., Cardinaels, R., den Toonder, J.M.J. & Peneda Pacheco, D. (2021). Engineered modular microphysiological models of the human airway clearance phenomena. Biotechnol Bioeng. 118, 3898-3913, <a href="http://dx.doi.org/10.1002/bit.27866" target="_blank"><u>http://dx.doi.org/10.1002/bit.27866</u></a>. This work demonstrates ad hoc mucus models of physiological and pathological mucus are combined with magnetic artificial cilia to model mucociliary transport in both physiological and pathological states. The modular concept adopted in this study enables the development of mucociliary clearance models with high versatility since these can be easily modified to reproduce phenomena characteristic of healthy and diseased human airways while allowing to determine the effect of each parameter and/or structure separately on the overall mucociliary transport. The data are experimentally obtained with methods described in the publication.</p>
%I 4TU.ResearchData