%0 Generic
%A Fu, Shengling
%A Zhou, Yu-cong
%A Fang, Hu
%A Ouyang, Haoliang
%A Li, Shihua
%A Xiao, Jinping
%A Liu, Hao
%D 2024
%T Data underlying the publication: Neuroprotective Effects of Everolimus via Regulation of Autophagy-Related Proteins in a Cerebral Ischemia-Reperfusion Rat Model
%U 
%R 10.4121/983ad43d-4fad-4808-ade9-d30a03d836bb.v1
%K Cellular autophagy
%K mTOR
%K Beclin-1
%K ischemic stroke
%K everolimus
%K Middle cerebral artery occlusion (MCAO)
%K pPI3K
%K PI3K
%K pAkt
%K Akt
%X <p>The data was collected from MCAO rats to evaluate the neuroprotection of everolimus. In excel file, the Longa’s neurological scale was applied to evaluate neurobehavioral deficit in ischemia/reperfusion-induced rats, and the ischemic infarct area of each section was calculated as infarct size. Besides, immunochemical staining of MCAO rats for mTOR and Beclin-1 expression was uploaded to observe the influence of everolimus on mTOR and Beclin-1. Besides, the data also included WB images of pPI3K, PI3K, pAkt, Akt, LC3-I, LC3-II. This study explored the effect of everolimus on the expression of PI3K, LC3, and Akt proteins and further clarified the regulatory mechanism of nerve cell autophagy against neural lesions.</p>
%I 4TU.ResearchData