%0 Generic
%A Weener, Huub
%A van Haaps, Thijs
%A van Helden, Ruben
%A Albers, Hugo
%A Haverkate, Rozemarijn
%A Middelkamp, Heleen
%A Ridderikhof, Milan
%A van Mens, Thijs
%A van den Berg, Albert
%A Mummery, Christine
%D 2024
%T Data of manuscript Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19
%U 
%R 10.4121/5bb846d8-ed30-4e2e-bfe3-4fb607cbe8ed.v1
%K Clinical data
%K ELISA
%K Thrombosis
%K Organ-on-Chip
%K RNA sequencing
%K Cytokine
%K COVID-19
%K Corona
%X <p>This dataset contains the data for the manuscript "Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19", to be published. Within the data are multiple sets:</p><ul><li>clinical data from included patients and controls; including admission time in hospital, diagnostic measurements when first included, outcome of admission, and VTE status during admission</li><li>Cytokine ELISAs of IL-6, IL-10, TNF-a, IFN-y, CXCL-10, measured in the derived plasma of hospitalized patients</li><li>Raw reads of RNA sequencing of hiPSC derived endothelial cells, after cells were stimulated with diluted patient plasma overnight to induce changes in their phenotype</li><li>Raw pathogen counts based on said RNA sequencing data, where non-human RNA reads are quantified per sample</li><li>Platelet coverage data after hiPSC-ECs were stimulated with derived plasma on-chip, where the stimulated chips were perfused with human whole blood to recapitulate the thrombotic adverse events that occur in some COVID patients.</li></ul>
%I 4TU.ResearchData