%0 Generic
%A van der Net, Anouk
%A Rahman, Zaid 
%A Deep Bordoloi, Ankur 
%A Muntz, Iain
%A ten Dijke , Peter
%A Boukany, Pouyan
%A Koenderink, G.H. (Gijsje)
%D 2024
%T Data underlying the publication: Unjamming transitions in cancer cell spheroids are linked to EMT-dependent cell-matrix interactions
%U 
%R 10.4121/3af75b5a-db30-419c-97ab-a5f632812a6c.v1
%K hydrogel
%K melanoma cancer
%K lung cancer
%K cancer invasion
%K unjamming
%K TGF-β
%K Matrix metalloproteases
%X <p>Datasets for the publication "Unjamming transitions in cancer cell spheroids are linked to EMT-dependent cell-matrix interactions", to be submitted.</p><p>Datasets include the raw tif files of 3D spheroid invasion assays of A549 and MV3 spheroids embedded in collagen (2.4 and 8 mg/mL) and gelMA (30 and 50 mg/mL). This include time-series bright-field imaging for 24 hrs (MV3) and 72 hrs (A549) at one hour interval. The spheroids were treated with exogenous TGF-β and broad spectrum MMP-inhibitor and imaged under same conditions.</p><p>Datasets include MATLAB/.m codes to analyze the spheroid images for effective spheroid radius, number of disseminated cells, rate of invasion and protrusion length. Additionally, MATLAB codes/.m to plot figures are also included within each respective condition. Raw data for supplementary data is also provided as images, excel files and MATLAB scripts.</p>
%I 4TU.ResearchData