cff-version: 1.2.0 abstract: "Goal: The aim of the project was to investigate whether S.aureus proteins SPIN and 6PGD via the formation of the hybrid auto-antigen SPIN:MPO or MPO mimitope 6PGD could explain the differential aetiologies of the disease GPA (Granulomatosis with polyangitis) caused by MPO-ANCA (Anti Neutrophil Cytoplasmic Autoantibodies).Methods: Isolation kinetic verification of S.Aureus 6PGD and SPIN by means of Activity measurements, see Readme for further specifications. Determination of antibody reactivity/titers using ELISA in sera from patients with MPO ANCA and healthy individuals against the hybrid auto-antigen MPO:ANCA or 6PGD, see Readme for further specifications. Data: Antibody titers ELISA and (Kinetics) colorigenic activity assays.
" authors: - family-names: Bianchi given-names: Frans orcid: "https://orcid.org/0000-0002-9385-9695" - family-names: Heeringa given-names: Peter - family-names: Frans given-names: Myrthe orcid: "https://orcid.org/0000-0002-6672-0946" - family-names: van der Veen given-names: Anna - family-names: van der Ven given-names: Jildau title: "Data underlying the research of the Role of bacterial proteins in the onset of ANCA vasculitis" keywords: version: 1 identifiers: - type: doi value: 10.4121/17171069.v1 license: CC BY 4.0 date-released: 2022-01-18