cff-version: 1.2.0
abstract: "<p>All primary chemical interactions weaken under mechanical stress, which imposes fundamental mechanical limits on the materials constructed from them. Biological materials combine plasticity with strength, for which nature has evolved a unique solution: catch bonds, supramolecular interactions that strengthen under tension. Biological catch bonds use force-gated conformational switches to convert weak bonds into strong ones. To date, catch bonds remain exclusive to nature, leaving their potential as mechano-adaptive elements in synthetic systems untapped. Here, we report the design and realization of artificial catch bonds. Starting from a minimal set of thermodynamic design requirements, we created a molecular motif capable of catch bonding. It consists of a DNA duplex featuring a cryptic domain that unfolds under tension to strengthen the interaction. We show that these catch bonds recreate force-enhanced rolling adhesion, a hallmark feature of biological catch bonds in bacteria and leukocytes. This work introduces catch bonds into the synthetic domain.</p>"
authors:
  - family-names: van Galen
    given-names: Martijn
  - family-names: Bok
    given-names: Annemarie
  - family-names: Peshkovsky
    given-names: Taieesa
  - family-names: van der Gucht
    given-names: Jasper
  - family-names: Albada
    given-names: Bauke
  - family-names: Sprakel
    given-names: Joris
    orcid: "https://orcid.org/0000-0001-6532-4514"
title: "Dataset underlying publication: De novo DNA-based catch bonds"
keywords:
version: 2
identifiers:
  - type: doi
    value: 10.4121/96e43d14-80a6-46e2-819c-9c627cedf10e.v2
license: CC BY 4.0
date-released: 2024-04-30