cff-version: 1.2.0
abstract: "<p>This dataset supports the study <em>“Broad and specific anti-defense genes in bacteriophage genomes”</em> and contains experimental and computational data used to investigate how phages overcome bacterial immune systems. The research objective was to identify and functionally characterize phage-encoded genes that either broadly inhibit multiple bacterial defense pathways or specifically target individual systems. Data were collected through comparative genomics of diverse phage genomes, systematic genetic screens, molecular cloning, and infection assays measuring bacterial survival and phage propagation. The dataset includes the phylogenetic tree of all analysed phages, the protein alignment and HMM profiles of the identified anti-genes and the corresponding code that was used.</p>"
authors:
  - family-names: van den Berg
    given-names: Daan Frits
    orcid: "https://orcid.org/0000-0002-2217-4074"
  - family-names: Costa
    given-names: Ana Rita
    orcid: "https://orcid.org/0000-0001-6749-6408"
  - family-names: Brouns
    given-names: Stan
    orcid: "https://orcid.org/0000-0002-9573-1724"
title: "Data underlying the publication: Broad and specific anti-defense genes in bacteriophage genomes"
keywords:
version: 1
identifiers:
  - type: doi
    value: 10.4121/81c9f2ce-25e2-4f62-bee5-a5cafa0d20c0.v1
license: CC BY 4.0
date-released: 2025-09-01