cff-version: 1.2.0 abstract: "

Datasets for the publication "Unjamming transitions in cancer cell spheroids are linked to EMT-dependent cell-matrix interactions", to be submitted.

Datasets include the raw tif files of 3D spheroid invasion assays of A549 and MV3 spheroids embedded in collagen (2.4 and 8 mg/mL) and gelMA (30 and 50 mg/mL). This include time-series bright-field imaging for 24 hrs (MV3) and 72 hrs (A549) at one hour interval. The spheroids were treated with exogenous TGF-β and broad spectrum MMP-inhibitor and imaged under same conditions.

Datasets include MATLAB/.m codes to analyze the spheroid images for effective spheroid radius, number of disseminated cells, rate of invasion and protrusion length. Additionally, MATLAB codes/.m to plot figures are also included within each respective condition. Raw data for supplementary data is also provided as images, excel files and MATLAB scripts.

" authors: - family-names: van der Net given-names: Anouk - family-names: Rahman given-names: Zaid orcid: "https://orcid.org/0000-0003-1154-2764" - family-names: Deep Bordoloi given-names: Ankur - family-names: Muntz given-names: Iain orcid: "https://orcid.org/0000-0002-8434-8316" - family-names: ten Dijke given-names: Peter - family-names: Boukany given-names: Pouyan orcid: "https://orcid.org/0000-0002-2262-5795" - family-names: Koenderink given-names: G.H. (Gijsje) orcid: "https://orcid.org/0000-0002-7823-8807" title: "Data underlying the publication: Unjamming transitions in cancer cell spheroids are linked to EMT-dependent cell-matrix interactions" keywords: version: 1 identifiers: - type: doi value: 10.4121/3af75b5a-db30-419c-97ab-a5f632812a6c.v1 license: CC BY 4.0 date-released: 2024-04-10