cff-version: 1.2.0
abstract: "<div><div>Goal: The aim of the project was to investigate whether S.aureus proteins SPIN and 6PGD via the formation of the hybrid auto-antigen SPIN:MPO or MPO mimitope 6PGD could explain the differential aetiologies of the disease GPA (Granulomatosis with polyangitis) caused by MPO-ANCA (Anti Neutrophil Cytoplasmic Autoantibodies).</div><div>Methods: Isolation kinetic verification of S.Aureus 6PGD and SPIN by means of Activity measurements, see Readme for further specifications. </div><div>Determination of antibody reactivity/titers using ELISA in sera from patients with MPO ANCA and healthy individuals against the hybrid auto-antigen MPO:ANCA or 6PGD, see Readme for further specifications. </div><div>Data: Antibody titers ELISA and (Kinetics) colorigenic activity assays.</div></div><div><br></div>"
authors:
  - family-names: Bianchi
    given-names: Frans
    orcid: "https://orcid.org/0000-0002-9385-9695"
  - family-names: Heeringa
    given-names: Peter
  - family-names: Frans
    given-names: Myrthe
    orcid: "https://orcid.org/0000-0002-6672-0946"
  - family-names: van der Veen
    given-names: Anna
  - family-names: van der Ven
    given-names: Jildau
title: "Data underlying the research of the Role of bacterial proteins in the onset of ANCA vasculitis"
keywords:
version: 1
identifiers:
  - type: doi
    value: 10.4121/17171069.v1
license: CC BY 4.0
date-released: 2022-01-18