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Video recordings associated vith the pubblication: Focused ultrasound neuromodulation on MEA

dataset
posted on 25.11.2021, 10:11 by Marta SaccherMarta Saccher, Shinnosuke Kawasaki, Martina Proietti Onori, Geeske M. van Woerden, Vasiliki Giagka, Ronald Dekker
This dataset contains the video recording associated with the publication.
In the first video, the multiwell MEA has been used to test the temperature variation during the period of US-ON. A thermocouple type K was placed at the bottom of the well and the ultrasound transducer immersed in the well. The input voltage was the same as the one used during the cell experiment and the MEA plate was placed on top of a hot plate to reproduce the experimental conditions. After 60 seconds of ultrasound the temperature increase was 0.8 °C.
In the second video, the heat profile generated by the ultrasound transducer used for the ultrasound neuromodulation experiment is observed using the Schlieren system. The trasnduecr is placed in the same Schlieren setup configuration used to validate the ultrasound field and a thermocouple is placed close to the tip of the transducer. The ultrasound is turned on for 60 seconds with a driving voltage 4.5 times higher than the one used during the cell experiment. It can be seen that the heat profile generated by the trasducer remains rather shallow the tip of the transducer and the water surface, suggesting that the heat does not reach the neuronal culture and it is dispersed at the liquid surface, rather than towards the neurons.

Funding

Accelerating Innovation in Microfabricated Medical Devices

European Commission

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Unravelling the function of CAMK2 in brain development and its role in neurodevelopmental disorders.

Netherlands Organisation for Scientific Research

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History

Publisher

4TU.ResearchData

Format

.mp4

Organizations

TU Delft, Faculty of Electrical Engineering, Mathematics and Computer Science, Department of Microelectronics; Department of Neuroscience, Erasmus MC, Rotterdam, the Netherlands; Department of Clinical Genetics, Erasmus MC, Rotterdam, the Netherlands