Data underlying the publication "Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress"
datasetposted on 10.09.2020 by N. C. A (Nicole) van Engeland, F. (Freddy) Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, O. M. J. A. (Oscar) Stassen, D. (Daniel) Antfolk, R.C.H. (Rob) Driessen, S. (Saku) Ruohonen, Suvi T. Ruohonen, S. (Salla) Nuutinen, Eriika Savontaus, S. (Sandra) Loerakker, Kayla J. Bayless, M. (Marika) Sjöqvist, C. V. C (Carlijn) Bouten, John E. Eriksson, C. M. (Cecilia) Sahlgren
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
The data and resulting publication combine in vivo animal studies on mice, cell biological in vitro experiments and computational modeling to study the role of the intermediate filament protein vimentin as a mechanosensitive regulator of Notch signaling and arterial remodeling. The dataset consists of computational simulation, fluorescence-assisted cell sorting, immunofluorescence and histological staining, luciferase reporter assay, quantitative real-time polymerase chain reaction and Western blotting data.
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