van Engeland, Suarez Rodriguez (2019) data.zip (252.62 MB)

Data underlying the publication "Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic stress"

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posted on 10.09.2020 by N. C. A (Nicole) van Engeland, F. (Freddy) Suarez Rodriguez, Adolfo Rivero-Müller, Tommaso Ristori, Camille L. Duran, O. M. J. A. (Oscar) Stassen, D. (Daniel) Antfolk, R.C.H. (Rob) Driessen, S. (Saku) Ruohonen, Suvi T. Ruohonen, S. (Salla) Nuutinen, Eriika Savontaus, S. (Sandra) Loerakker, Kayla J. Bayless, M. (Marika) Sjöqvist, C. V. C (Carlijn) Bouten, John E. Eriksson, C. M. (Cecilia) Sahlgren
The data and resulting publication combine in vivo animal studies on mice, cell biological in vitro experiments and computational modeling to study the role of the intermediate filament protein vimentin as a mechanosensitive regulator of Notch signaling and arterial remodeling. The dataset consists of computational simulation, fluorescence-assisted cell sorting, immunofluorescence and histological staining, luciferase reporter assay, quantitative real-time polymerase chain reaction and Western blotting data.

Funding

Targeting Notch signalign in cancer

Academy of Finland

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The integration of cell signalling and mechanical forces in vascular morphology

European Research Council

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Intelligent materials for in-situ heart Valve tissue engineering

European Commission

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Doctoral Network of Molecular Biosciences at Åbo Akademi University

The Finnish Foundation for Cardiovascular Research

Maud Kuistila Memorial Foundation

The Swedish Cultural Foundation in Finland

Einar & Karin Stroems foundation

History

Publisher

4TU.ResearchData

Time coverage

2016-2019

Organizations

Åbo Akademi University, Faculty of Science and Engineering, Biosciences; Eindhoven University of Technology, Department of Biomedical Engineering; Åbo Akademi University and University of Turku, Turku Bioscience; Medical University of Lublin, Department of Biochemistry and Molecular Biology; Texas A&M University Health Science Center, Department of Molecular & Cellular Medicine; University of Turku, Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology; Eindhoven University of Technology, Institute of Complex Molecular Systems; University of Turku, Turku Center for Disease Modelling

Licence

Exports