Data underlying the article: A Revised Modular Approach to (–)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions
datasetposted on 14.10.2019, 00:00 by Victor Bloemendal, D. (Daan) Sondag, H. (Hidde) Elferink, T.J. (Thomas) Boltje, Jan van Hest, F.P.J.T. (Floris) Rutjes
A revised modular approach to various synthetic (–)-trans-Δ8-THC derivatives through late-stage Suzuki–Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp2- and sp3-hybridized cross-couplingpartners with minimal β-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki–Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.