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Data underlying the article: A Revised Modular Approach to (–)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions

dataset
posted on 14.10.2019 by Victor Bloemendal, D. (Daan) Sondag, H. (Hidde) Elferink, T.J. (Thomas) Boltje, Jan van Hest, F.P.J.T. (Floris) Rutjes
A revised modular approach to various synthetic (–)-trans-Δ8-THC derivatives through late-stage Suzuki–Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp2- and sp3-hybridized cross-couplingpartners with minimal β-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki–Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.

Funding

H2020-FETOPEN-2016- 2017, 737266

History

Contributors

Radboud University, Institute for Molecules and Materials

Publisher

4TU.Centre for Research Data

Format

media types: application/pdf, application/x-rar-compressed, application/zip

Licence

Exports